Autoantibodies to mitochondrial 2‐oxo‐acid dehydrogenase complexes in localized scleroderma
نویسندگان
چکیده
منابع مشابه
Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma.
BACKGROUND Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies. OBJECTIVE To determine the presence or levels of antibodies (Abs) against matrix metalloproteinase (MMP)-1 and their clinical relevance in LSc. METHODS Anti-MMP-1 Ab was examined by ELISA (Enzyme-Linked ImmunoSorbent Assay) and immunoblotting using human recombinant MMP-1. MMP-1 collage...
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The clinical presentation of scleroderma in childhood is even more varied than in adult life. This study of 19 children shows that antinuclear antibodies (ANA) detected on the HEp2 cell substrate are just as common as in the adult disorders. All seven children with diffuse scleroderma or acrosclerosis were ANA positive, as were eight of the 12 with more localised disease. Antinucleolar antibodi...
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Morphea (localized scleroderma) is an autoimmune disease characterized by sclerosis of the skin and, in some cases, subcutaneous tissue. It occurs in children and adults. It is distinct from systemic sclerosis, but may nevertheless be associated with significant functional and cosmetic impairment. Morphea has several distinct subtypes, including circumscribed, linear, and generalized, all of wh...
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Background: There is no data on the characteristics of patients with localized scleroderma in Iran. Objective: In order to determine the age, sex and type distribution of localized scleroderma in Iran, this study was done on patients referred to Boo-Ali Hospital in Tehran in 1995-1999. Patients and Methods: This study was done as an existing data study on 39 patients with localized scleroderma ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 1996
ISSN: 0009-9104,1365-2249
DOI: 10.1046/j.1365-2249.1996.d01-756.x